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Carm1 Gene Detail
Summary
  • Symbol
    Carm1
  • Name
    coactivator-associated arginine methyltransferase 1
  • Synonyms
    Prmt4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913208
    NCBI Gene: 59035
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21458163-21500763 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    843 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913208
 protein coding gene Chr9:21458163-21503919 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034456
 protein coding gene Chr9:18799856-18821787 (+)
A/J MGP_AJ_G0034434
 protein coding gene Chr9:18443162-18487974 (+)
AKR/J MGP_AKRJ_G0034361
 protein coding gene Chr9:18801883-18848997 (+)
BALB/cJ MGP_BALBcJ_G0034425
 protein coding gene Chr9:18328401-18371506 (+)
C3H/HeJ MGP_C3HHeJ_G0034137
 protein coding gene Chr9:19089269-19140726 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034946
 protein coding gene Chr9:19529426-19579744 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031876
 protein coding gene Chr9:17557264-17600868 (+)
CAST/EiJ MGP_CASTEiJ_G0033460
 protein coding gene Chr9:18926678-18970590 (+)
CBA/J MGP_CBAJ_G0034110
 protein coding gene Chr9:20284089-20335850 (+)
DBA/2J MGP_DBA2J_G0034269
 protein coding gene Chr9:18412152-18455985 (+)
FVB/NJ MGP_FVBNJ_G0034212
 protein coding gene Chr9:17946307-17991547 (+)
LP/J MGP_LPJ_G0034354
 protein coding gene Chr9:18905703-18972815 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034255
 protein coding gene Chr9:21851263-21899373 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034966
 protein coding gene Chr9:18744155-18792162 (+)
PWK/PhJ MGP_PWKPhJ_G0033166
 protein coding gene Chr9:18407173-18452459 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033000
 protein coding gene Chr9:18796428-18846138 (+)
WSB/EiJ MGP_WSBEiJ_G0033575
 protein coding gene Chr9:18467826-18515470 (+)



Homology
more
  • Human Ortholog
    CARM1, coactivator associated arginine methyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARM1, coactivator associated arginine methyltransferase 1
  • Synonyms
    PRMT4
  • Links
    NCBI Gene ID: 10498
    neXtProt AC: NX_Q86X55
    UniProt: Q86X55

  • Chr Location
    19p13.2; chr19:10871553-10923075 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 5 alleles in 7 genetic backgrounds
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null fetuses are small and die perinatally, whereas heterozygotes are born at the expected Mendelian ratio but show decreased survival through weaning. Mice homozygous for a kinase null allele exhibit neonatal lethality, arrested T cell development, and impaired adipogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    916
  • Tissues
    133
  • cDNA Data
    15
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59035 NCBI Gene Model | MGI Sequence Detail 42601 C57BL/6J ±  kb
    transcript NM_001411233 RefSeq | MGI Sequence Detail 3767 ZRU/MplStud  
    polypeptide Q9WVG6 UniProt | EBI | MGI Sequence Detail 608 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 15
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5505487
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 25
      Gene Ontology 19
      Phenotypes 32
    • Earliest
      J:64957 Chen D, et al., Regulation of transcription by a protein methyltransferase. Science. 1999 Jun 25;284(5423):2174-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory